What issues can occur if you run OneDrive for Business 2013 and SharePoint Workspace 2010 on the same computer?

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The article How to install the OneDrive for Business sync client for SharePoint 2013 and SharePoint Online recommends you uninstall SharePoint Workspace before installing OneDrive for Business, but then implies you can run the two together, if Office 2010 is upgraded to SP2 (Service Pack 2) before you install OneDrive for Business. This post addresses the usual questions about this configuration.

Is it supported?

This configuration is not recommended. However, the following instances are supported:

Are there any issues if I follow these procedures?

The only established issue is with starting a sync from a remote library – for example, your OneDrive for Business library, or a SharePoint Team site library. When you click Sync from the library, the operation should start the sync application most recently installed or repaired. For Office compatibility guidelines, this should always be the more recent version. However, we have seen cases in which SharePoint Workspace is started instead. If you run both sync clients, you may need to create syncs manually from the client UI.

Because Office 2010 updates may violate the version order of installation repair, it is possible that other issues may occur that lead to cache corruption in a sync or difficulty opening Office files from the cloud in a local application. You should be able to prevent this by always repairing the 2013 client after Office 2010 updates are applied. 

What can I do if I installed OneDrive for Business before updating Office 2010 to SP2?

Save any unsynced data, uninstall OneDrive for Business, repair the Office 2010 installation, and then reinstall OneDrive for Business.