If I had a nickel for each time I heard that one. It’s a great question too, and one that sometimes isn’t as easy to answer as you might think. Fortunately for us, the esteemed Kevin Holman has compiled a a fantastic list of hotfixes that you should be considering if you manage any kind of OpsMgr environment. In his own words:
In general - you should evaluate all hotfixes available, and only apply those applicable to your environment. However, some of these below I have seen impact almost every environment, and should be heavily considered.
This list is nothing official.... this is just a general list of the recommended hotfixes I end up proactively applying to most environments.... it is not a complete list of ALL hotfixes, and you may be affected by other issues.
We point customers to this list all the time and have found that often times simply following Kevin’s advice will resolve many issues all by itself. If you haven’t seen it then this is one you’ll want to bookmark:
J.C. Hornbeck | Manageability Knowledge Engineer