I was recently asked if there is any way to disable protected mode in IE7 via GPO for a set of users. First off, I highly recommend against disabling protected mode. There are substantial security benefits gained by having it enabled. It would be far better to put the site or sites in the trusted sites zone and adjust settings accordingly. If you need to modify these settings via GPO you can, there is an MSDN site with information to understand protected mode and with guidance on managing it through GPO.