This will be the first version of App-V to support both x64 and x86 Windows platforms. The primary focus of this release is to enable App-V to take advantage of 64-bit Windows platforms including Windows 7 and Windows Server 2008 R2. We’ve also made some improvements in the App-V Sequencer such as simplifying the workflow for creating virtual applications and adding the ability to sequence true 64-bit applications, a first to market! For customers running Windows XP or Windows Vista, you can also use App-V 4.6 Beta and take advantage of the support for Office 2010, 64-bit platform support and additional features in the release.
See the MDOP Blog for additional details and a link to the Microsoft Connect site to download App-V 4.6