You may receive the following error when running a scheduled data refresh of a PowerPivot workbook in SharePoint 2016:
The virtual path '/......xlsx' maps to another application, which is not allowed.
After this error occurs, the schedule gets disabled and the schedule settings are deleted. The schedule keeps getting disabled even if the following scheduled refreshes run successfully.
This error is caused by a bug in PowerPivot. The fix will be released in the sppowerpivot16.msi file in the Feature Pack for the upcoming release of SQL Server 2016 SP2.